By: Dr. Andrew Krause ND CSCS CISSN, Ontario Regional Manager, Cyto-Matrix
One of my favourite parts of my role with Cyto-Matrix is how often I get to see colleagues at their clinics, and hear about their clinical successes in practice. One product that has been getting particular mention in meetings over the past few months is Bio-Ferra.
Bio-Ferra is a liquid iron that uses a form of iron called Polyaccharide Iron Complex (PIC). We chose to use this form of iron in Bio-Ferra for three reasons:
1. PIC is a non-ionic form of iron, which means it does not need high stomach acid to be absorbed. This runs contrary to many other forms of iron that are prominent on the market, since an ionic form of iron requires high stomach acid to break the bond between the iron and whatever agent has been bound to it. Common agents bound to iron are: gluconate, fumarate, succinate, and bisglycinate. (1)
2. PIC is also significantly less constipating than other forms of iron, and therefore encourages better compliance than with other forms of iron (Bio-Ferra also has a palatable green apple taste). PIC has a higher lethal dose (LD50) than any other form of iron on the market (2,3), which makes it safe, along with being tolerable.
a. Bio-Ferra has been on the market for 26 months as of this writing, and we have yet to have a patient call in and complain about constipation related to the product!
3. PIC is a vegan source of iron! At Cyto-Matrix, we are always mindful of ensuring that our products can be used by the largest proportion of patients possible, so this was an important feature when choosing PIC.
Now that you understand the “why” behind Bio-Ferra, here are some of the clinical results we’ve seen and heard from clinicians using Bio-Ferra in practice over the last 2 years.
1. A pregnant patient was able to double her ferritin (16 to 32mcg/L) in two weeks with 2 teaspoons of Bio-Ferra per day, even considering her 1L of blood loss during the birthing process.
2. One clinician has had 4 cases in the past year where giving 2 tsps per day of Bio-Ferra doubles the patient’s ferritin levels in 3-6 months.
3. Another pregnant patient was able to raise her ferritin from 16 to 52 mcg/L with 3tsp per day dosing in 6 weeks, having also lost blood during the birthing process.
Among the many other iron products on the Canadian natural health product market, Bio-Ferra is a safe option that limits constipation, and is clinically effective at improving the symptoms of iron deficiency.
1. Ma et al. Effects of Different Doses and Duration of Iron Supplementation on Curing Iron Deficiency Anemia: an Experimental Study. Biol Trace Elem Res (2014) 162:242–251
2. Oral Iron for Anemia: A Review of the Clinical Effectiveness, Cost-effectiveness and Guidelines. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 Jan.
3. Klein-Schwartz, Wendy. Toxicity of Polysaccharide–Iron Complex Exposures Reported to Poison Control Centers. Ann Pharmacother 2000; 34:165-9.
Written by: Emily Elliot
Edited by: Ali Cockerill
Many patients concerned with acne arrive at the naturopathic doctor perplexed and frustrated as they express, ‘I have tried everything and nothing works!’ While the number of ‘acne fighting’ products that line the shelves of drug stores and supermarkets are constantly growing and promises of clear skin are endless, the treatment of acne is complex and the exact science has not yet been discovered. While the exact pathogenesis of acne is still largely a topic of scientific investigation, the good news is that many lifestyle changes have well documented results. Additionally, acknowledging that as patients that their hormonal status is unique may be a starting place for answers. While expensive lotions and creams are an excellent addition to a proper skin care regiment, acne is truly a journey from the inside out. Our skin is a very important messenger that can offer us insight into what is happening internally. Let’s review some of the strategies that are effective for clearing up the skin.
Mastering your meals, the best diet for acne:
The debate on whether or not diet contributes to acne is longstanding. However, studies are finally identifying what dermatologists have always truly known – yes, there is definitely a link between diet and breakouts. It is no coincidence that some non- Westernized populations report almost zero occurrence of acne lesions! (1)
Specifically, studies have shown reduced acne lesions and the associated improvements in insulin sensitivity with the consumption of a lower glycemic diet (RCI) (1). A diet in higher glycemic foods will ultimately spike blood sugars leading to increased androgens and IGF-1, which increases secretion of oil and clogs pores.
A low glycemic diet for acne should include lots of healthy fats (olive oil, fatty fish, nuts and seeds), plenty of fibre (25 g for women and 38 g for men), lots of dark leafy greens and an appropriate protein calculation for one’s body weight (a minimum of 0.8g/Kg of body weight). The anti-acne diet should also minimize dairy products as they have also been linked to increased IGF-1 production.
Focusing on lymph is no waste:
Exercise recommendations for the patient with acne can be met with some resistance. Fears may emerge regarding how ‘sweat build up’ may detriment the skin. However, it is important to focus on the benefits that come from regular exercise and to promote proper hygiene practices before and after workouts. Many patients working with acne have issues detoxifying and may display signs of a sluggish lymphatic system like: allergies, itching, chronic fatigue etc. Recommendations like cycling, running, walking, yoga and ‘rebounding’ (trampoline jumping) have all been documented for their lymphatic benefits (2). Through daily movement and generating lymphatic flow, the body brings forth oxygen and nutrients to the skin’s surface as it works to eliminate cellular debris and waste products that can build up in acne (3). There really is no substitute for a healthy, active lifestyle. Explaining the mechanics of lymphatic detox may empower the patient to see how movement can positively promote their anti-acne efforts.
Tame hormonal havoc:
Once diet and lifestyle have been approached, hormonal status is a vital part of the acne investigation. Hormonal acne is often linked to the menstrual cycle and can appear around the region of the chin, hairline and back. High androgens (testosterone and its breakdown product dihydrotestosterone) are frequently cited as a hormonal cause of acne (voice changes, hair loss on the head, irregular menstrual cycles in women, weight gain etc.)(4). However, it is important to rule out other hormonal presentations that could use balancing. For example, are there signs of high progesterone (depression, weight gain and increased fat storage, poor blood sugar balance) or low progesterone (hair loss, anxiety, increased allergies, sluggish metabolism etc.) (4). Testosterone, estrogen and progesterone all keep each other in fine balance, so don’t forget to assess all three of these important hormones. (Note: high cortisol can be implicated in testosterone production as well, a quick check on cortisol status may be well indicated too).
Skin superstars: In general, improving skin vitality and health relies on a few key players. Typical recommendations are Vitamin A 25000-50000 IU (contraindicated in pregnancy), Vitamin C 1000-5000 mg and Zinc 15-25 mg, making Cyto-Matrix’s ‘ACEs and Zinc’ truly a ‘skin basic’ (5). Reduced levels of serum zinc have also been identified in patients with increased acne lesions making it an excellent addition to the anti-acne treatment plan (1).
Essential fatty acids are also crucial in maintaining that healthy skin glow we all long for. EFAs found in Cyto-Matrix’s Omega D3 liquid forte not only hydrate the skin and replenish the skin’s barrier but also offer anti-inflammatory properties that are highly beneficial in an inflamed condition like acne. An important focus in skincare is not just combating the condition but also promoting the formation of healthy skin in general.
Boosting bowel terrain:
Oral probiotics help to reduce systemic inflammation and oxidative stress that are characteristic of acne as well as modulate IGF-1, one of the primary proteins linked to acne proliferation. The benefits of supplementation have also been documented for patients who are taking antibiotic treatment and suffering from the side effects of these treatments. One study showed the synergistic benefit of taking probiotics with minocycline when compared to the antibiotic alone as the combination group showed the greatest reduction in acne lesions when compared to the other controls (6).
Mindful medicine for acne:
The emotional effects of acne can be intense and extensive. One important study revealed that even in patients with mild acne, there were feelings of low self-esteem, depression and suicidal thoughts (7). Checking in on one’s overall journey with acne and validating their frustration is a crucial part of patient care and may hold one of the final pieces of the puzzle. When mind, body and soul are all honored as part of the patient’s journey, the truest healing begins.
(1) Logan, C and Treloar, V. The Clear Skin Diet. Naperville, IL. Cumberland House Publishing.
(2) Exercise for the Lymphatic System. (2016). Retrieved from http://cancercompassalternateroute.com/detox/various-exercises-for-the-lymphatic-system/#
(3) The Lymphatic System. (2013). Retrieved from http://www.lymphnotes.com/article.php/id/151/
(4) Turner, N. The Hormone diet. USA. Random House.
(5) Natural Ways to Treat and Prevent Acne. (October 2012). Retrieved from http://www.huffingtonpost.ca/natasha-turner-nd/natural-adult-acne-solutions_b_1952491.html
(6) Kober, M and Bowe, W. (2014). The Effect of Probiotic on Immune Regulation, Acne and Photoaging: International Journal of Women’s Dermatology , 1 (85-89).
(7) Dunn, L. (2011). Acne in Adolescents: Quality of life, self-esteem, mood and psychological disorders: Dermatology Online Journal, 17 (1): 1.
By: Dr. Andrew Krause ND CSCS CISSN
Ontario Regional Representive
Quick Summary: Provitalex is an unflavoured protein powder that is made from milk of North America grass fed cows. It’s minimally processed with cold water, which maintains the proteins in their natural undenatured since it is treated without heat. We use cross flow microfiltration which maintains larger amounts of beneficial immune components, antioxidants, essential amino acids, and minerals as opposed to lower quality protein powders that lose these beneficial ingredients during processing. Provitalex mixes well without the need of a blender and doesn’t sit heavy in the stomach, which makes it easy for someone on the go. At 20.24g of protein per 22g scoop, and 5g of BCAAs per scoop, Provitalex is an excellent choice of protein for you and your patients.
I’ve used or prescribed each and everyone one of the Cyto-Matrix products at one point or another, and if there’s one product that I’m confident that almost every patient could use regardless of their health concerns or health goals, it’s Provitalex.
Protein powder is an ingredient that blends the line between medical food and supplement. Regardless of the kind of protein powder (vegetarian, vegan, milk based, beef based, or cricket based), it’s an ingredient that supplements a MACRO nutrient (carbohydrate, protein, or fat), which is unlike 90% of the natural health products on the market, which typically supplement MICRO nutrients. I qualify it as a medical food in my practice, just like I would a greens powder product or fish oil.
As a macronutrient, protein is something that is necessary for many different processes in the body, from immune function, to hair growth, to muscular health. The RDA (recommended dietary allowance) of protein is 0.8g of protein per kilogram of body weight. Both men and women have the same protein requirement; pregnant and lactating women do have a slightly increased need though (1.1g/kg and 1.3g/kg respectively) (1)
Now, the thing to know about the 0.8g/kg number is that this level is necessary to only meet adequacy for basic body functions. This doesn’t take into account the increased need for protein when you’re stressed (which is frequent), when you’re under slept (often), or when you’re exercising (hopefully 30 minutes per day!). Athletes can require between 1.2 and 1.7g protein kg body weight because of their increased muscular damage and stress on the body. (1)
For simplicity, I tell patients to eat 1g of protein per kilogram of body weight if they are inactive, and 1.5g/kg if they exercise over 3 days a week. This amounts to 64 g for someone who is 150lbs and inactive, and around 85g of protein for someone who is 200lbs and inactive. For active individuals, 96g for a 150lb individual and 127g protein for a 200lb individual.
Going overboard on protein isn’t a problem- there are large amounts of research that show that excess protein is not bad for the body, not even for the kidneys. This is especially true when you are eating enough vegetables as well. In research that showed that excess protein is a bad thing, patient’s diets were devoid in vegetables as well; if you get both protein and vegetables in adequate levels, you’re in the clear and on the way to optimal nutrition. However, going over 2g/kg bodyweight also hasn’t shown any benefit. (2)
What is Whey Protein Isolate anyways?
• Whey protein isolate is actually a molecule formed by several smaller proteins: beta lactoglobulin, alpha lactalbumin, glycomacropeptides, immunoglobulins, bovine serum albumin, and lactoferrin
What about dairy intolerance?
• When someone experiences non-allergic symptoms from dairy, there can be a few explanations for those symptoms
o Lactose intolerance- ~15% of the adult population is lactose intolerant in Canada. Patients typically experience bloating, indigestion, and flatulence as main symptoms (3)
o IgG mediated milk protein intolerance- not very conclusively tied to symptoms, since IgG to milk protein rises regardless of the presence of symptoms in adults (4). This occurs in 3-5% of the childhood and adult population (5) This is predominantly an intolerance to casein, not whey.
o Therefore, even if someone is lactose intolerant or casein intolerant, a cross flow micro filtered whey protein isolate would most likely be suitable to consume.
Whey Protein Isolate (WPI) is my preferred protein for personal use and for my patients for 5 main reasons:
• WPI is well researched for muscle health
o Increases muscle protein synthesis related to exercise (6), prevents muscle loss in old age (7)
• WPI is a high quality protein powder
o Highest PDCAAS, BV, and PER of any protein powders (vegan or otherwise) on the market. These 3 scores measure the body’s ability to breakdown, process, and make amino acids available in the body. (8)
• WPI has a high BCAA content
o Around 22% of the proteins in whey protein isolate are branched chain amino acids, which have been shown to be helpful with exercise endurance and in stimulating recovery after exercise. (8)
• WPI increases glutathione levels (9)
o This boosts antioxidant status in the body and recovery from exercise (10) and can benefit psoriasis (11)
• It has a lower allergen content that casein and whey protein concentrate
o A decrease amount of lactose, casein, and beta lactaglobulin makes whey protein isolate much more tolerable for patients than other dairy-based protein options
There are two ways to make a whey protein isolate (WPI):
Ion Exchange- This method is a chemical method that requires a low pH environment (by the addition of sodium hydroxide and hydrochloric acid) to separate the protein from the carbohydrate and fat that is native to dairy. Through this process, many of the beneficial fractions of whey protein are lost, as are the antioxidants, calcium, some essential amino acids, and naturally occurring proteases in milk. There is also heat involved in this process, which denatures some of the remaining proteins as well. This inevitably changes the taste of the protein as well- leaving it tasting somewhat salty and more processed.
Ion Exchange Whey has beta-lactoglobulin as the main protein fraction (70%) which is the most allergenic of the proteins in WPI, and the one without positive immune effects. (12)
Cross Flow Microfiltered- This is the method used to make Provitalex. This method uses cold water and pressure gradients, so there are no solvents involved to purify the whey protein. The milk is passed through ceramic filters in order to filter the whey, leaving an undenatured end product. Membrane filtration leaves whey protein isolate tasting similar to milk.
Beta-lactoglobulin is present to a lower degree in Provitalex, only 48% of total protein content, and has alphalactalbumin, lactoferrin, and immunoglobulins that are present to a much lower degree in Ion Exchange Whey. These bioactive protein fractions provide an important immune benefit to whey protein isolate and render cross flow microfiltration an overall superior product. (12)
Lastly, we chose not to flavor Provitalex so it can be used in any and all situations, from smoothies, to baking, to savory recipes if you would like. No sweet flavours here!
All in all, if you are having trouble reaching your protein levels based on your needs, you want to use whey protein isolate for it’s specific benefits, or you just need a more convenient way to ingest your daily protein, Provitalex protein is a great way to do so.
1. Canadian Sociey of Exercise Professionals. Protein for Active Canadians. CSEP. http://csep.ca/CMFiles/publications/dfc/Protein_booklet_e.pdf
2. American Dietetic Association, Dietitians of Canada, American College of Sports Medicine. American College of Sports Medicine position stand. Nutrition and athletic performance. http://journals. lww.com/acsm-msse/Fulltext/2009/03000/ Nutrition_and_Athletic_Performance.27.aspx
3. Barr SI. Perceived lactose intolerance in adult Canadians: a national survey. Appl Physiol Nutr Metab2013;38:830-835.
4. Anthoni S, Savilahti E, Rautelin H, Kolho KL. Milk protein IgG and IgA: The association with milk-induced gastrointestinal symptoms in adults. World J Gastroenterol 2009 October 21; 15(39): 4915-4918
5. Peltoi L, Impivaara O, Salminen S, Poussa P, SeppaÈnen R, Lilius E-M. Milk hypersensitivity in young adults. European Journal of Clinical Nutrition (1999) 53, 620±624
6. Elliot, T.A., M. G. Cree, A. P. Sanford, R. R. Wolfe, and K. D. Tipton (2006). Milk ingestion stimulates net muscle protein synthesis following resistance exercise. Med. Sci. Sports Exerc. 38: 667-674.
7. Pennings, B., Y. Boirie, J. M. Senden, A. P. Gijsen, H. Kuipers, and L. J. van Loon (2011). Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. Am. J. Clin. Nutr. 93: 997-1005.
8. Campbell, B, Kreider, R, Ziegenfuss, T, La Bounty, P, Roberts, M, Burke, D, Landis, J, Lopez, H, Antonio, J. International Society of Sports Nutrition position stand: protein and exercise. Journal of the International Society of Sports Nutrition 2007, 4:8
9. Zavorsky GS1, Kubow S, Grey V, Riverin V, Lands LC. An open-label dose-response study of lymphocyte glutathione levels in healthy men and women receiving pressurized whey protein isolate supplements. Int J Food Sci Nutr. 2007 Sep;58(6):429-36.
10. Sheikholeslami Vatani D1, Ahmadi Kani Golzar F.Changes in antioxidant status and cardiovascular risk factors of overweight young men after six weeks supplementation of whey protein isolate and resistance training. Appetite. 2012 Dec;59(3):673-8. doi: 10.1016/j.appet.2012.08.005. Epub 2012 Aug 10
11. Prussick R1, Prussick L, Gutman J.Psoriasis Improvement in Patients Using Glutathione-enhancing, Nondenatured Whey Protein Isolate: A Pilot Study. J Clin Aesthet Dermatol. 2013 Oct;6(10):23-6.
12. Sutherland J. Membrane vs. Ion Exchange – Which Process is Best for Whey Protein Powder?. Milk Specialties. http://www.milkspecialties.com/news/membrane-vs-ion-exchange-which-process-is-best-for-whey-protein-powder/
By Dr. Michelle Cali
National Scientific Advisor
We all are familiar with garlic as a multi-purpose anti-infective agent. With one of the longest histories as a medicinal food and, now, with a plethora of empirical evidence, garlic is reputed for its powerful ability to resolve even the most hostile of infections. This can be critically important in a time where new resistant strains of bacteria are emerging. New research has proven this natural agent’s effectiveness against the most feared, MRSA.
How does it work? Let’s review. Garlic’s active ingredient, allicin, is recognizable by its distinctive pungent odour. This oxygenated sulphur compound is created upon crushing or chewing raw garlic when its stable precursor, alliin comes into contact with allinase. Supplemental garlic can offer a concentrated form of this bioactive ingredient but are they all created equal? One hurdle companies have in dealing with garlic is the fact that allicin and its metabolites are quick acting and extremely unstable. Thus, making it difficult to capture in supplemental form. Cyto-Matrix’s Garlic Active Principles uses CO2 Supercritical Extraction to encapsulate allicin’s allyl sulfides and vinyldithiins in highly concentrated form.
So, is this the agent to use in unpretentious nagging infections? One of the most common chronic viral infections I see in practice is the common wart – an HPV infection causing skin growths that can last from months to years. Although not a dangerous infection, these lesions can be unsightly and can multiply over surfaces of hands, feet among other areas. They also may indicate an underlying need for immune support.
These are the cases in which I know I can rely on a trusted friend, garlic. But I have come to understand that potency and product matters. With its concentrated form of garlic’s bioactive components, Cyto-Matrix’s Garlic Active Principles works hard against HPV with minimal dosing. Depending on the severity of the lesions, I usually dose 2 capsules a day along with the basic immune support of 2 ACES+Zn and simple dietary considerations. This combination has shown powerful action against warts with patients revealing significant reduction in lesions in approximately 3 weeks and full resolution in 5-8 weeks (within 2 follow-up visits). In two severe cases, I initiated this treatment with a homeopathic anti-viral combination but found resolution time to be about the same. After complete resolution we discontinue the garlic supplementation and continue immune support if needed.
Although I turn to garlic supplements for many infection related issues, it is these simple cases that highlight its effectiveness for persistent infections and immune support.
By Dr. Elias Markou, ND
Medical Director, Cyto-Matrix
As spring roles around we are all either preparing our selves for a good deep cleanse or preparing a total detox program for our patients to complete. My experience over the years has been patients are looking for something new or the next best thing when they come to you looking for a detox or cleanse. If you are giving them the same old cleanse every year, you probably won’t retain that patient for long. So take a few minutes to reflect on what your patients want to see and do in a cleanse.
Our Cytomatrix Detoxification Program is a great way to package everything your patients needs for a quick and easy detox. Our Bio-B6, DT-Matrix, Mito-Matrix and the Provitalex Pure Whey are all you need for this biologically powerful detox. The Liver and the kidneys are the two most important organs in this program, our product formulations and selections make for a complete cleanse.
Every cleanse should have a vitamin B6 formulation. The Bio-B6 is a nice formulations made up of pyridoxal 5′-phosphate and pyridoxine hydrochloride (the active forms of vitamin B6) often depleted by many toxic substances. A vitamin B6 deficiency makes it difficult for the liver to detoxify.
Our DT-Matrix is an intelligent formulation that supports both the liver and kidney functions during the detoxification process. The key ingredient Milk Thistle is a favourite liver detoxifying herb among naturopathic doctors. You can find mounds of academic research online about milk thistle. This formulation is a winner.
A detoxification program is not complete with out a powerful synergistic free radical quencher. Our Mito-Matix formulation, targets the root of all cellular metabolism, the mitochondria. The N-Acetyl-L-carnitine, alpha lipoic acid, N-Acetyl-L-cysteine and the coenzyme Q10 all support deep cellular detoxification.
And finally every detox program should have an amino acid profile that can drive phase two of liver function. The Provitalex Pure Whey is packed with significant amounts of glycine, glutamine, taurine, methionine and cysteine that can power any toxin out of the body.
Choose Cyto-Matrix products and save your patients the time and energy by giving them a new cleanse every year, you will see them come back happy and detoxified.
By Dr. Andrew Krause, ND CSCS CISSN
You probably know someone that has taken an iron supplement in their lifetime; you may have even taken one yourself. And what is the most common complaint?
It can get so bad that patients would rather not take an iron product at all rather than feel the effects of some products, which is one of the worst outcomes a healthcare practitioner can have as they are trying to help someone. It’s extremely frustrating to have picked the right ingredient at the right dose, only to have compliance be the limiting factor.
Thankfully, a new formulation of iron was developed that is able to virtually eliminate the side effect potential of taking an iron supplement, while reliably raising ferritin levels.
Iron Polysaccharide Complex is a non-ionic form of iron that is available as a liquid in Bio-Ferra™. It provides 100% elemental iron, which is a significantly higher percentage relative to other forms of iron on the market. (1)
Non-ionic iron is an important distinction to look for when choosing an iron, because the splitting into ions in the stomach is the main reason that patients will experience an upset stomach and constipation when taking typical iron supplements.
When there is an increase in the number of ions in the stomach, more water is drawn to the stomach (through ADH secretion) to dilute this elevated concentration of ions. In order to do this, water is pulled away from the lower gastrointestinal system, making stools harder, and more difficult to pass. (2)
By limiting this process altogether, constipation is virtually eliminated with BioFerra™. Bio-Ferra™ delivers the highest dose of elemental iron in a liquid product (20mg/teaspoon) in a palatable green apple flavour that makes compliance effortless, especially for children and the elderly.
1. Manoguerra AS, Erdman AR, Booze LL, Christianson G, Wax PM, Scharman EJ, et al. Iron ingestion: an evidence-based consensus guideline for out-of-hospital management. Clin Toxicol (Phila) 2005;43:553-70.
2. Oh MS. Evaluation of renal function, water, electrolytes, and acid-base balance. In: McPherson RA, Pincus MR, eds. Henry’s Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia, Pa: Elsevier Saunders; 2011:chap 14.